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Nicotinamide mononucleotide (NMN) supplementation also restores mitochondrial function, suppresses ROS and apoptosis, and improves ART outcomes ( Finally, folic acid has been observed to influence in vitro oocyte maturation and gene expression patterns ( 2.2 Antioxidant activity Oxidative stress, which is a major contributor to oocyte aging, is mitigated by antioxidant supplements that operate downstream of mitochondrial dysfunction by directly neutralizing oxidative damage through exogenous radical scavenging and endogenous defense potentiation, thereby enhancing cellular redox balance and preserving oocyte genomic integrity and developmental competence ( Euterpe oleracea exhibits variable effects on antioxidant pathways and cell growth by upregulating -adrenergic signaling while downregulating apoptosis and proinflammatory signaling ( In vitro studies using HGL5 cells, melatonin has been demonstrated to restore glycolysis, tricarboxylic acid (TCA) cycle activity, and redox balance, effectively protecting oocytes (Tsui et al., 2024)

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Before and after L-carnitine supplementation, patients were asked to complete the Chronic Fatigue Questionnaire (20)

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